Table 2. Epidermal phenotype of integrin knockout mice
Integrin subunitPhenotypeReference
α3Disorganized basement membrane; occasional epidermal/dermal blistering, primarily on legs and footpadsDiPersio et al. (1997)
β6Juvenile hair loss due to macrophage infiltration into skin; wound healing normalHuang et al. (1996)
α9No defects observedHuang et al. (2000b)
β5Wound healing normalHuang et al. (2000a)
β1Floxed β1 × K5CreBrakebusch et al. (2000)
Abnormal hair follicles; hair loss with removal of follicles by infiltrating macrophages; epidermal/dermal blisters; reduced proliferation and abnormal differentiation of IFE; disruption of basement membrane; reduced α6β4 expression; reduced hemidesmosomes; dermal fibrosis; impaired wound healingGrose et al. (2002)
Floxed β1 × K14CreRaghavan et al. (2000)
Epidermal/dermal blistering; basement membrane disruption; reduced hemidesmosomes; thin epidermis; reduced number of hair follicles; reduced α6β4 expression
α6Severe epidermal blisteringGeorges‐Labouesse et al. (1996)
β4Severe epidermal blistering; absence of hemidesmosomesvan der Neut et al. (1996)
Dowling et al. (1996)
α3 + α6Epidermal blistering; proliferation, stratification and hair follicle morphogenesis normal in adherent epidermisDiPersio et al. (2000a)
α2No epidermal defects observed, wound healing not impairedChen et al. (2002)
Holtkötter et al. (2002)