Ligand | ∆C_{p} [cal mol^{−1} K^{−1}] | ∆ASA_{min} [Å^{2}] (with ∆c_{min} = 0.45) | ∆ASA_{max} [Å^{2}] (with ∆c_{max} = 0.24) |
---|---|---|---|
GTP | −553 ± 11a | 1,229 | 2,304 |
GTPγS | −539 ± 30b | 1,198 | 2,254 |
GDPNP | −197 ± 26b | 433 | 820 |
GDP | −228 ± 10b | 507 | 950 |
∆C_{p}, heat capacity change; obtained from ∆H/dT.
∆c_{min} and ∆c_{max} area coefficients in cal K^{−1} (mol Å^{2})^{−1} for calculation of ∆ASA.
∆ASA_{min} and ∆ASA_{max}, changes in solvent accessible surface areas assuming that all changes were conferred by either apolar or 70% apolar and 30% polar surfaces, respectively.
↵a Obtained from (Kuhle & Ficner, 2014).
↵b Obtained from the slope of the linear fit to ∆H measured at different temperatures between 10 and 30°C.