Table 1. This table summarizes the involvement of TETs and methylcytosine oxidation in neuronal diseases
TETs/hmC connection in neuronal diseases
PathologiesObservationsReferences
Rett syndromeDecrease of MeCP2 binding on 5hmC Kriaucionis & Heintz (2009)

Mellen et al (2012)
PsychosisGAD67 promoter hyper‐hydroxymethylation Dong et al (2012)

Matrisciano et al (2012)
Global increase of 5hmC

Increase of TET1 expression
Dong et al (2012)

Guidotti et al (2012)

Auta et al (2013)
Huntington's diseaseDecrease of 5hmC on ADORA2A promoterVillar‐Menendez et al (2013)
Global decrease of 5hmC

Decrease of TET1 expression
Wang et al (2013)
Friedreich's ataxiaGlobal increase of 5hmCAl‐Mahdawi et al (2013)
Fragile X syndrome Global decrease of 5hmC on gene bodies and promoters

Subtle increase of 5hmC on enhancers and repetitive elements
Yao et al (2013)
Alzheimer's disease Global increase of 5hmC in hippocampus

Global decrease of 5hmC in temporal tissues
Coppieters et al (2014)

Chouliaras et al (2013)