Table 3. Molecular architecture of β2GPI
 Tilt (°)Twist (°)Buried area (Å2)Linker
CCP1–CCP2∼0∼115320TPRV
CCP2–CCP3∼30∼110207APII
CCP3–CCP4∼55∼40335REVK
CCP4–domain V∼55∼ −50318KAS
Tilt and twist angles are defined as described by Bork et al. (1996). The angles are calculated based on the conserved Trp residues, which are used to define the repeat axes (Bork et al., 1996) (except for CCP4–domain V). The program GRASP (Nicholls et al., 1991) was used to calculate the buried surface area for one accessible molecular surface per module.