Inactivation of the type I interferon pathway reveals long dsRNA‐mediated RNAi in mammalian cells
While RNAi is a known antiviral mechanism in plants and invertebrates, its contribution in mammals is only revealed upon ablation of the interferon pathway.
The diverse and expanding role of mass spectrometry in structural and molecular biology
Albert Heck and colleagues showcase how state‐of‐the‐art mass spectrometry approaches have evolved into powerful tools to elucidate structure and function of proteins and protein complexes.
Polarized cortical tension drives zebrafish epiboly movements
Hydrodynamic regression is used to infer mechanical parameters from microscopy data obtained during epiboly in zebrafish. This novel approach identifies a polarized gradient of cortical tension as the driver of tissue movements.