Nutrient sensing and TOR signaling in yeast and mammals
As part of our metabolism focus, this review summarizes how nutrient availability is recognized and integrated by the conserved TOR cell growth regulator.
A G1‐like state allows HIV‐1 to bypass SAMHD1 restriction in macrophages
Terminally differentiated macrophages displaying a Raf/MEK/ERK pathway‐dependent G1‐like cell cycle expression profile are permissive to HIV‐1 infection due to deactivation of the host HIV‐1 restriction factor SAMHD1
Inactivation of the type I interferon pathway reveals long dsRNA‐mediated RNAi in mammalian cells
While RNAi is a known antiviral mechanism in plants and invertebrates, its contribution in mammals is only revealed upon ablation of the interferon pathway.