Myc is one of the original reprogramming factors used to produce induced pluripotent stem cells. However, it is not necessary, instead its main role is to increase the efficiency of the reprogramming. The article by Scognamiglio et al (2016) helps clarify how. The authors show that Myc depletion leads to a reversible dormant state consistent with diapause. In this state, the cell sees its proliferation potential diminished but its pluripotency unchanged. The ability to coordinate the induction of this state should have important implications in cell differentiation.
See also: R Scognamiglio et al (February 2016)
Pluripotency can be divided into two states: naïve and primed. These two states represent different stages in development and are distinguishable in mice, with the naïve state reflecting cells from the inner cell mass, while those in the primed state reflecting cells post‐implantation (Nichols & Smith, 2009). These different states describe different developmental potential, as naïve state pluripotent stem cells can be used to …
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