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Mec1 and Tel1: an arresting dance of resection

Tracey Beyer, Ted Weinert

Author Affiliations

  1. Tracey Beyer1 and
  2. Ted Weinert (tweinert{at}email.arizona.edu) 1
  1. 1Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, USA
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Abstract

At sites of damage DNA is resected to enable the optimal form of repair, directed by homology. But how does the cell regulate resection while coordinating with the cell cycle? In this issue of The EMBO Journal, Clerici et al define missing links between DNA resection and cell cycle arrest during repair, showing that Mec1 can inhibit resection to subsequently activate arrest by Tel1.

Footnotes

  • The authors declare that they have no conflict of interest.

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