Cover: Wound‐associated epithelial cells migrate over and cover wounds during intestinal repair. Prostaglandin E2 regulates an adaptive cellular reprogramming mechanism during repair, in which differentiating epithelial cells are directed away from the typical enterocyte lineage and towards the wound‐associated epithelial cell lineage to promote healing (depicted by illustration). Fluorescent images depict intestinal epithelial cell spheroids differentiated to enterocytes (left) or wound‐associated epithelial cells (right) and stained for beta‐catenin (green) and F‐actin (red). From Hiroyuki Miyoshi, Kelli L VanDussen, Thaddeus S Stappenbeck and colleagues: Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. For details, see the Article on p 5, also highlighted by Jackstadt and Sansom on p 3. Scientific images and cover concept by Hiroyuki Miyoshi, Kelli VanDussen and Thaddeus Stappenbeck, Washington University, St Louis, MO, USA (Illustration by Uta Mackensen).