Phosphoinositides (PIs) form a minor class of phospholipids with crucial functions in cell physiology, ranging from cell signalling and motility to a role as signposts of compartmental membrane identity. Phosphatidylinositol 3‐phosphates are present at the plasma membrane and within the endolysosomal system, where they serve as key regulators of both cell signalling and of intracellular membrane traffic. Here, we provide an overview of the metabolic pathways that regulate cellular synthesis of PI 3‐phosphates at distinct intracellular sites and discuss the mechanisms by which these lipids regulate cell signalling and membrane traffic. Finally, we provide a framework for how PI 3‐phosphate metabolism is integrated into the cellular network.
The EMBO Journal (2016) 35: 561–579
- Received November 25, 2015.
- Revision received January 15, 2016.
- Accepted January 26, 2016.
- © 2016 The Authors
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