Coordinated regulation of vesicle trafficking is critical for the proper functioning of a cell. The bulk of cellular transport vesicles are sequestered in a “perinuclear cloud”, with only a small fraction released to the cell periphery. Jongsma et al (2016) found that the ER‐associated E3 ubiquitin ligase RNF26 is responsible for establishing and maintaining the architecture of the perinuclear cloud and that this spatiotemporal positioning is critical for effective regulation of the endocytic and exocytic systems.
See also: MLM Jongsma et al (June 2016)
In order to maintain intracellular homeostasis in a changing environment, cells must continually shuttle cargo between cellular compartments, take in nutrients, and respond to signals from the extracellular space. These complex tasks are accomplished by the coordinated activities of the endocytic and exocytic systems. Endosomes derived from the plasma membrane can either recycle their cargo back to the cell surface or undergo maturation into late endosomes/multi‐vesicular bodies (MVBs). MVBs then fuse either with lysosomes for degradation, or with the plasma membrane for the release of secretory exosomes. In the exocytic system, newly synthesized proteins are trafficked from the endoplasmic reticulum (ER) to the Golgi apparatus and the trans‐Golgi network (TGN) from which they are disseminated in secretory vesicles to their final destinations. There is significant cross talk between …
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