microRNAs (miRNAs) are a family of small, non‐coding RNAs, which provides broad silencing activity of mRNA targets in a sequence‐dependent fashion. This review explores the hypothesis that the miRNA machinery is intimately linked with the cellular stress pathway and apparatus. Stress signaling potentially alters the function of the miRNA‐bioprocessing core components and decompensates regulation. In addition, dysregulation of miRNA activity renders the cell more prone to stress and emerges as a new pathway for age‐related insults and diseases, such as neurodegeneration.
The EMBO Journal (2014) 33: 1428–1437
- Received February 10, 2014.
- Revision received March 23, 2014.
- Accepted March 28, 2014.
- © 2014 The Authors