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FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function

Kim Steen Jensen, Tina Binderup, Klaus Thorleif Jensen, Ib Therkelsen, Rehannah Borup, Elise Nilsson, Hinke Multhaupt, Caroline Bouchard, Bjørn Quistorff, Andreas Kjær, Göran Landberg, Peter Staller

Author Affiliations

  1. Kim Steen Jensen1,
  2. Tina Binderup2,3,
  3. Klaus Thorleif Jensen1,
  4. Ib Therkelsen4,
  5. Rehannah Borup5,
  6. Elise Nilsson6,
  7. Hinke Multhaupt1,
  8. Caroline Bouchard7,
  9. Bjørn Quistorff4,
  10. Andreas Kjær2,3,
  11. Göran Landberg6,8 and
  12. Peter Staller*,1,
  1. 1 Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark
  2. 2 Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark
  3. 3 Cluster for Molecular Imaging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
  4. 4 Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
  5. 5 Department of Clinical Biochemistry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
  6. 6 Department of Laboratory Medicine, Center for Molecular Pathology, Lund University, Malmö University Hospital, Malmö, Sweden
  7. 7 Institute of Molecular Biology and Tumour Research, Philipps‐University of Marburg, Marburg, Germany
  8. 8 Breakthrough Breast Cancer Research Unit, School of Cancer and Enabling Sciences, Manchester Academic Health Science Centre, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK
  1. *Corresponding author. Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen DK‐2200, Denmark. Tel.: +45 3532 5682; Fax: +45 3532 5669; E‐mail: peter.staller{at}
  • Present address: EpiTherapeutics, Copenhagen, Denmark. E‐mail: ps{at}

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