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The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy

Simona Pedrotti, Pamela Bielli, Maria Paola Paronetto, Fabiola Ciccosanti, Gian Maria Fimia, Stefan Stamm, James L Manley, Claudio Sette

Author Affiliations

  1. Simona Pedrotti1,2,
  2. Pamela Bielli1,2,
  3. Maria Paola Paronetto2,
  4. Fabiola Ciccosanti3,
  5. Gian Maria Fimia3,
  6. Stefan Stamm4,
  7. James L Manley5 and
  8. Claudio Sette*,1,2
  1. 1 Department of Public Health and Cell Biology, University of Rome Tor Vergata, Rome, Italy
  2. 2 Laboratory of Neuroembryology at CERC, Fondazione Santa Lucia, Rome, Italy
  3. 3 Spallanzani Hospital, Rome, Italy
  4. 4 Department of Biochemistry, University of Kentucky, Lexington, KY, USA
  5. 5 Department of Biological Sciences, Columbia University, New York, NY, USA
  1. *Corresponding author. Department of Public Health and Cell Biology, University of Rome ‘Tor Vergata’, Via Montpellier, 1, Rome 00133, Italy. Tel.:+3906 7259 6260; Fax: +3906 7259 6268; E-mail: claudio.sette{at}
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