Spatial organization of adhesion: force‐dependent regulation and function in tissue morphogenesis

Ekaterina Papusheva, Carl‐Philipp Heisenberg

Author Affiliations

  1. Ekaterina Papusheva1 and
  2. Carl‐Philipp Heisenberg*,1,
  1. 1 Institute of Science and Technology Austria, Klosterneuburg, Austria
  1. *Corresponding author. Pfotenhauerstrasse 108, D‐01307 Dresden, Germany. Tel.: +49 351 210 2712; Fax: +49 351 210 1489; E-mail: heisenberg{at}
  • Present address: Max‐Planck‐Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr.108, D‐01307 Dresden, Germany

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Integrin‐ and cadherin‐mediated adhesion is central for cell and tissue morphogenesis, allowing cells and tissues to change shape without loosing integrity. Studies predominantly in cell culture showed that mechanosensation through adhesion structures is achieved by force‐mediated modulation of their molecular composition. The specific molecular composition of adhesion sites in turn determines their signalling activity and dynamic reorganization. Here, we will review how adhesion sites respond to mecanical stimuli, and how spatially and temporally regulated signalling from different adhesion sites controls cell migration and tissue morphogenesis.

  • Received June 15, 2010.
  • Accepted July 9, 2010.
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